Biomarkers and Clinical Outcome Measures

Sources covering [BIOMARKER] machinery (validation, qualification, milestones, assay qualification), clinical / cognitive scales (UPDRS / MDS-UPDRS, MoCA, H&Y, SCOPA-AUT, RBDQ-HQ), RBD / RBD PDD/DLB, NFL in PD, SILK, retinal / Rob Rubens material, synaptic change in PD, and reference ranges.

Source-of-truth pages live in data/processed/markdown/by-photo/. Each row below points first to the KB source note (which carries the heading list) and then to the canonical transcription.

Sources in this section: 27

Top-level nav clusters: 22

[BIOMARKER]

3 source pages

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20240722_184733	Page 1243 of 1252	[BIOMARKER] > Validation > Analytical (=Technical) validation	note	md
20240722_184736	Page 1243 of 1253	[BIOMARKER] > Validation > Analytical (=Technical) validation	note	md
20240722_184740	Page 1249 of 1258	[BIOMARKER] > Examples of biomarker > Keytruda with MSI-H or dMMR	note	md

Outcome measures

3 source pages

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20240722_184300	Page 981 of 988	Outcome measures > Original UPDRS (1987)	note	md
20240722_184303	Page 984 of 990	Outcome measures > Original UPDRS (1987) > MDS-UPDRS’ = Modified… > (Simuni, 2018 #198)	note	md
20240722_184450	Page 1085 of 1095	Outcome measures > Sandy > Screenig > Scientst.com > Schizophrenia	note	md

NFL

2 source pages

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20240722_184213	Page 934 of 945	NFL	note	md
20240722_184253	Page 974 of 980	NFL > PD	note	md

BIOMARKER

1 source page

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20240722_184723	Page 1234 of 1242	BIOMARKER > Validity > Milestones > Milestone: MBM Only	note	md

biomarkers

1 source page

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20240722_184506	Page 1097 of 1109	biomarkers	note	md

GT

1 source page

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20240722_184344	Page 1025 of 1030	GT > Cell therapy > Inflammation > 기타 MOA들	note	md

MOA of NPC

1 source page

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20240722_184250	Page 964 of 975	MOA of NPC > NFL > Age > PD	note	md

MoCA (Montreal Cognitive Assessment)

1 source page

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20240722_184306	Page 984 of 992	MoCA (Montreal Cognitive Assessment)	note	md

MoCA (Montreal Cognitive…

1 source page

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20240722_184456	Page 1088 of 1100	MoCA (Montreal Cognitive…	note	md

Navigation pane shows: polygenic risk score > Steps of PRS STUDY; visible document/status context shows biomarker validation / FDA Biomarker qualification material

1 source page

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20240722_184730	Page 1237 of 1248	Navigation pane shows: polygenic risk score > Steps of PRS STUDY; visible document/status context shows biomarker validation / …	note	md

RBD

1 source page

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20240722_184434	Page 1066 of 1078	RBD	note	md

RBDQ-HO (REM sleep…

1 source page

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20240722_184545	Page 1133 of 1145	RBDQ-HO (REM sleep…	note	md

Reference range (normal range)

1 source page

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20240722_184557	Page 1147 of 1157	Reference range (normal range)	note	md

Retina

1 source page

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20240722_184440	Page 1072 of 1084	Retina > Issues Retina > Rob Rubens	note	md

Rob Rubens

1 source page

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20240722_184600	Page 1147 of 1161	Rob Rubens	note	md

SCOPA-AUT

1 source page

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20240722_184503	Page 1094 of 1106	SCOPA-AUT > Shipment > Sigma-1 Receptor (σ1R) > σ1R PET > SILK	note	md

SILK

1 source page

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20240722_184613	Page 1164 of 1173	SILK	note	md

Succinate

1 source page

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20240722_184513	Page 1106 of 1116	Succinate > Surrogate endpoint > Symptom > Synapse	note	md

Synapse

1 source page

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20240722_184519	Page 1112 of 1122	Synapse > Neuronal pentraxins > Synaptic change in PD > Target Identification > TDP43 > TMEM106B > TMEM175	note	md

Synaptic change in PD

1 source page

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20240722_184626	Page 1177 of 1186	Synaptic change in PD	note	md

Transfer

1 source page

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20240722_183327	Page 775 of 782	Transfer > Team > Translational questions > RBD+PD	note	md

Validation

1 source page

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20240722_184726	Page 1237 of 1244	Validation > Biomarker milestones > BMx Assay Qualification > Biomarker type-specific definition of milestones	note	md

Cross-References

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