Source 20240722_182811

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Page labelPage 498 of 504
Navigation pathPipeline of GD & GBA-PD > Supplement > Other Biobanks > Biobanks in Japan > BIOMARKER > BioOrchestra > Dose finding > Delayed start design
SectionGBA-PD, GD, and α-Synuclein Pipeline
Uncertain spans3
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Related photos2

Headings

  • GBA GT v2_GP sample-size tail, 20190423 Sclareol-NS imaging strategy 4-panel chart, Sample size calculation (proportion / Visions Pharmaceutical 2021 #1755 / Lundkya 2013), Innovative design / Interim analysis / β regression model / FDA-EMA principle, C-Path DAT Enrichment slide, Delayed start design (Liu-Seifert 2015 sketch), MEAN STRIATUM DAT vs AV133 table
  • DAT Enrichment allows ~24% Reduction of Trial Size to Detect a Disease modifying Drug Effect with 80% Power (slide)
  • Delayed start design
  • MEAN STRIATUM DAT vs AV133
  • Uncertain Spans

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